Liposomal formulation of a methotrexate lipophilic prodrug: assessment in tumor cells and mouse T-cell leukemic lymphoma

Anna A Alekseeva,1 Ekaterina V Moiseeva,1 Natalia R Onishchenko,1 Ivan A Boldyrev,1 Alexander Online S Singin,2,† Andrey P Budko,2 Zoya S Shprakh,2 Julian G Molotkovsky,1 Elena L Vodovozova1 1M.M.Shemyakin and Yu.A.Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 2N.N.Blokhin Russian Cancer Research Center, t

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The bumblebee Bombus terrestris carries a primary inoculum of Tomato brown rugose fruit virus contributing to disease spread in tomatoes.

The bumblebee Bombus terrestris is a beneficial pollinator extensively used in tomato production.Our hypothesis was that bumblebee hives collected from a Tomato brown rugose fruit virus (ToBRFV) infected tomato greenhouse, preserve an infectious primary inoculum.Placing a bumblebee hive collected from a ToBRFV contaminated greenhouse, in a glass-/n

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